After myocardial infarction, HF hospitalization risk is higher among women

  • Yandrapalli S & al.
  • Heart
  • 11 Jan 2021

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • Women have greater risk than men for heart failure (HF) hospitalization after acute myocardial infarction (MI).
  • The risk increase sets in soon after the MI.

Why this matters

  • Authors: given the early increase in risk, follow-up after discharge in the early post-MI phase may need to be evaluated to ensure optimization of outcomes.

Key results

  • Cohort included 237,549 patients who had an acute MI (71.9% non-ST-elevation).
  • Mean age, 66.9 years; 37.9% were female.
  • Some differences in comorbidities, age, risk factor history, and revascularization rates between women and men.
  • HF was more common among women at the index event:
    • 34.3% vs 26.1% among men (P<.001>
  • 5.4% of overall population had HF hospitalization within 6 months.
    • 6.8% of women vs 4.6% of men (P<.001>
  • 4.6% of the hospitalized group died during the hospitalization.
  • Fatality rate was similar between women and men.
  • Propensity-matched analysis showed higher HF hospitalization risk for women vs men:
    • HR, 1.13 (95% CI, 1.05-1.21).

Study design

  • Retrospective cohort analysis, US Nationwide Readmissions Database data from January to June 2014.
  • Funding: None disclosed.

Limitations

  • Claims-based data.
  • Outpatient HF diagnoses possibly missed.