- Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is quite prevalent and associated with inferior survival vs other forms of ALL.
- Survival is comparable vs Philadelphia-positive (Ph+) ALL.
Why this matters
- Ph-like ALL is a relatively new genetic subtype of ALL, first reported in 2009.
- Systematic review and meta-analysis to investigate the prevalence of, and outcomes in, Ph-like ALL.
- A search of MEDLINE and EMBASE yielded 15 studies comprising 11,040 patients with ALL and 1546 patients with Ph-like ALL.
- Funding: None disclosed.
- 15.4% (95% CI, 12.3%-19.1%) pooled prevalence of Ph-like ALL among studied ALL patients.
- Peak prevalence of Ph-like ALL was in the following age groups:
- Age 11-20 years: 26.2% (95% CI, 23.6%-28.9%).
- Age 21-40 years: 25.8% (95% CI, 22.1%-29.8%).
- 42.8% (95% CI, 23.9%-64.1%) pooled 5-year OS.
- Patients with Ph-like ALL had significantly lower chance of 5-year survival vs other B-cell ALL patients: pooled OR, 0.35 (95% CI, 0.25-0.50); P<.00001.>
- Patients with Ph-like ALL had comparable chance of 5-year survival vs Ph+ ALL patients: pooled OR, 0.72 (95% CI, 0.26-2.02); P=.53.
- Retrospective data.