- Androgen-deprivation therapy (ADT) in patients with prostate cancer is associated with the development of Alzheimer's disease.
Why this matters
- Clinicians considering treating prostate cancer with ADT may also want to consider the patient's risk for Alzheimer's disease as well.
- Patients were divided into 4 groups: non-ADT (patients who never received ADT; n=8401), patients who received injections for at least 3 mo (injection cohort [INJ]; n=1008), patients who received oral therapy for at least 3 mo (n=9963), and patients who received injections and oral medication (n=4905).
- Non-ADT incidence of AD was 2.78/1000 person-years and 5.66/1000 in the ADT cohort.
- Age-adjusted Cox proportional hazards regression model showed that the ADT cohort was 1.84 times more likely to develop dementia than the non-ADT group.
- Retrospective analysis of data from 24,360 patients with prostate cancer who were and were not receiving ADT for 4 y and analyzed the relationship between ADT and the development of dementia.
- Funding: None disclosed.
- Retrospective study design.
- Non-ADT patients were generally younger than ADT patients.