Anti-HDL lipid parameter increased rather than decreased in CHD patients receiving statin therapy

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  • HDL-apoCIII, which is associated wth congestive heart disease, was elevated in patients with CHD following statin therapy while other key lipid parameters were reduced

Study Design

  • Hospital-based observational study to investigate the association between HDL-apoCIII and congestive heart disease (CHD) and the effect of statin therapy on such levels in patients with CHD
  • Study population: 80 non-CHD patients and 120 CHD patients without statin treatment
  • All CHD patients received statin therapy and 63 of them were followed-up after 3 months of statin therapy

Key Results

  • Significantly higher HDL-apoCIII in patients with CHD vs patients without (P<.05)
  • Significantly elevated total plasma apoCIII in patients with CHD following statin therapy, whereas TC, LDL-C, and apoB were significantly decreased

Why This Matters

  • ApoCIII is believed to impair the anti-atherogenic properties of HDL-C in patients with CHD
  • The effects of statin therapy on apoCIII have remained unclear