- Patients with depression have a similarly elevated risk for dementia relative to the general population, whether they use antidepressants or not.
Why this matters
- Among patients with depression, compared with antidepressant nonusers, users had elevated risks for:
- Dementia (relative risk [RR], 1.37; 95% CI, 1.11-1.70).
- Mild cognitive impairment (RR, 1.20; 95% CI, 1.02-1.42).
- Compared with the general population, patients with depression had similarly elevated dementia risk whether they:
- used antidepressants (RR, 1.48; 95% CI, 1.21-1.81) or
- did not use antidepressants (RR, 1.31; 95% CI, 1.15-1.49).
- RR for dementia vs general population by antidepressant class:
- Selective serotonin reuptake inhibitors: 2.21 (95% CI, 1.44-3.40).
- Serotonin norepinephrine reuptake inhibitors and atypical antidepressants: 4.74 (95% CI, 3.06-7.36).
- Tricyclic antidepressants: 1.66 (95% CI, 1.20-2.31).
- Monoamine oxidase inhibitors: 1.37 (95% CI, 1.22-1.50).
- Systematic review, meta-analysis of longitudinal studies evaluating risks for dementia or mild cognitive impairment in patients with depression and/or antidepressant users.
- Analyses based on 18 studies with 2,119,627 participants (mean age range, 54.6-81.1 years).
- Main outcomes: dementia; mild cognitive impairment.
- Funding: None disclosed.
- Heterogeneity of studies, populations.
- Possible selection bias, confounding.