- Asthma and type 1 diabetes (T1D) co-occur within individual children, according to a large Swedish cohort study.
- Asthma is associated with increased T1D risk, but not vice versa.
- Siblings are also at risk for co-occurrence.
Why this matters
- Clinicians should maintain a high index of suspicion for familial co-aggregation when either disease presents in a child.
- Retrospective cohort study of 1,284,748 singleton children, live-born in Sweden (2001-2013).
- Children were linked to their biological full siblings, cousins, and half-cousins.
- Funding: Swedish Research Council; others.
- Asthma occurred in 9.5%, T1D in 0.3%.
- 494 (0.04%) had both conditions.
- Asthma and T1D were positively associated within an individual child.
- OR, 1.15 (95% CI, 1.05-1.27).
- Children with asthma had a higher risk for subsequent T1D.
- HR, 1.16 (95% CI, 1.06-1.27).
- Children with T1D did not have a higher risk for asthma.
- HR, 0.92 (95% CI, 0.75-1.12).
- Siblings of children with 1 condition were at increased risk for the other.
- OR, 1.27 (95% CI, 1.13-1.42).
- Full cousins of children with 1 disease were at marginally increased risk for the other.
- OR, 1.08 (95%CI, 1.00-1.17).
- No information on primary care diagnoses.