Atopic eczema patients at increased risk for CVD

  • Silverwood RJ & al.
  • BMJ
  • 23 May 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A population-based study suggests that adults with atopic eczema are at increased risk for cardiovascular disease (CVD).

Why this matters

  • Study helps clarify relationship between atopic eczema and cardiovascular outcomes.

Key results

  • Patients with mild atopic eczema had increased risk for unstable angina (HR, 1.25; 99% CI, 1.10-1.43), heart failure (HR, 1.12; 99% CI, 1.02-1.23), and coronary revascularization (HR, 1.12; 99% CI, 1.02-1.23).
  • Patients with moderate atopic eczema had increased risk for myocardial infarction (HR, 1.11; 99% CI, 1.01-1.23), unstable angina (HR, 1.22; 99% CI, 1.06-1.42), heart failure (HR, 1.25; 99% CI, 1.14-1.38), Afib (HR, 1.17; 99% CI, 1.08-1.27), stroke (HR, 1.14; 99% CI, 1.04-1.25), and coronary revascularization (HR, 1.14; 99% CI, 1.03-1.26).
  • Patients with severe atopic eczema had increased risk for myocardial infarction (HR, 1.41; 99% CI, 1.15-1.71), unstable angina (HR, 1.48; 99% CI, 1.08-2.03), Afib (HR, 1.38; 99% CI, 1.17-1.62), stroke (HR, 1.22; 99% CI, 1.01-1.48), cardiovascular death (HR, 1.38; 99% CI, 1.17-1.62), heart failure (HR, 1.69; 99% CI, 1.38-2.06), and coronary revascularization (HR, 1.47; 99% CI, 1.19-1.81).

Study design

  • 387,439 patients with atopic eczema and 1,528,477 matched control patients from the UK Clinical Practice Research Datalink, Hospital Episode Statistics, and Office for National Statistics were analyzed.
  • Funding: Wellcome.

Limitations

  • Observational study.

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