- Atopic eczema is associated with the development of depression and anxiety, according to a population study.
Why this matters
- This large study supports previously observed associations between atopic eczema and new depression/anxiety.
- Atopic eczema was associated with increased incidence of new depression (HR, 1.10; 95% CI, 1.10-1.12) and anxiety (HR, 1.12; 95% CI, 1.10-1.15) in adjusted analysis.
- Depression risk increased with atopic eczema severity (P<.0001 for linearity>
- Mild: HR, 1.10; 95% CI, 1.08-1.13.
- Moderate: HR, 1.19; 95% CI, 1.15-1.23.
- Severe: HR, 1.26; 95% CI, 1.17-1.37.
- 526,808 adult patients with atopic eczema and 2,569,030 matched control subjects were analyzed for associations with depression and anxiety.
- Funding: Wellcome Senior Research Fellowship in Clinical Science, Health Data Research UK.
- Potential misclassification of disease status or severity.
- Potential symptom reduction or resolution was not captured.