Atopic eczema tied to increased risk for depression, anxiety

  • Schonmann Y & al.
  • J Allergy Clin Immunol Pract
  • 31 Aug 2019

  • International Clinical Digest
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Takeaway

  • Atopic eczema is associated with the development of depression and anxiety, according to a population study.

Why this matters

  • This large study supports previously observed associations between atopic eczema and new depression/anxiety.

Key results

  • Atopic eczema was associated with increased incidence of new depression (HR, 1.10; 95% CI, 1.10-1.12) and anxiety (HR, 1.12; 95% CI, 1.10-1.15) in adjusted analysis.
  • Depression risk increased with atopic eczema severity (P<.0001 for linearity>
  • Mild: HR, 1.10; 95% CI, 1.08-1.13.
  • Moderate: HR, 1.19; 95% CI, 1.15-1.23.
  • Severe: HR, 1.26; 95% CI, 1.17-1.37.
  • The association between depression risk and atopic eczema was stronger in men (HR, 1.19; 95% CI, 1.16-1.23) vs women (HR, 1.11; 95% CI, 1.08-1.13; P<.0001>
  • The association between anxiety risk and atopic eczema was also stronger in men (HR, 1.22; 95% CI, 1.17-1.27) than women (HR, 1.14; 95% CI, 1.11-1.17; P=.0003).
  • Study design

    • 526,808 adult patients with atopic eczema and 2,569,030 matched control subjects were analyzed for associations with depression and anxiety.
    • Funding: Wellcome Senior Research Fellowship in Clinical Science, Health Data Research UK.

    Limitations

    • Potential misclassification of disease status or severity.
    • Potential symptom reduction or resolution was not captured.