- Low expression of inositol polyphosphate-5-phosphatase (INPP5A) is associated with reduced survival in patients with recurrent/metastatic cutaneous squamous cell carcinoma (cSCC).
Why this matters
- INPP5A represents the first biomarker for stratification of recurrent/metastatic cSCC.
- 78.8% of primary tumors had high INPP5A expression, while 21.2% had low expression.
- 69.2% of recurrent/metastatic disease tumors had high INPP5A expression, while 30.8% had low expression.
- Low vs high staining expression of INPP5A in the recurrent/metastatic disease tumor was associated with reduced OS (31.0 vs 62.0 months; P=.0272).
- INPP5A levels in the primary tumor were not significantly associated with OS (31.0 vs 57.0 months for low vs high, P=.0897).
- A composite risk score based on INPP5A expression in the primary and recurrent/metastatic tumors was associated with OS (HR, 0.42; P=.0113 for a score of 0 vs a score ≥1).
- 50 patients with recurrent/metastatic cSCC were analyzed for INPP5A staining and associations with survival.
- Funding: Dermatology Foundation, NIH.
- Retrospective study.
- Small patient sample size.