- Patients with invasive squamous cell carcinoma (SCC) of the bladder show worse prognosis vs those with urothelial carcinoma (UC) histology.
- Neoadjuvant chemotherapy (NACT) showed OS benefit in patients with UC vs radical cystectomy (RC) alone, but for not those with SCC histology.
Why this matters
- More effective therapies are needed for invasive SCC of the bladder.
- Study of 394,956 patients with bladder cancer from the National Cancer Database.
- Funding: None.
- 63,482 patients had clinically localized muscle-invasive bladder cancer; of those, 1.2% had SCC histology.
- At diagnosis, 70% of patients with SCC were presented with cT2-4 vs 19% of those with UC histology.
- OS was worse in patients with SCC vs UC clinically localized muscle-invasive bladder cancer (9.6 vs 24.6 months; P<.01 style="list-style-type:circle;">
- Worse OS was observed in patients with SCC across stages (all P<.01>
- Retrospective design.