Breast cancer: pertuzumab-related diarrhea is common, but manageable

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  • In both metastatic and early-stage HER2+ breast cancer treated with pertuzumab (Perjeta), the incidence of diarrhea is high (28%-72%), but dose-delays or discontinuations resulting from diarrhea are rare.
Why this matters
  • This study gives clinicians and patients information about the frequency and severity of diarrhea as an adverse effect of pertuzumab.
Study design
  • This study was a pooled analysis of a phase 3 trial of metastatic HER2+ cancer (CLEOPATRA, n=804) and 2 phase 2 trials (NeoSphere, n=416; TRYPHAENA, n=223).
  • Funding:  Genentech
Key results
  • Pertuzumab-based treatment had a high incidence of diarrhea (from 28% to 72%; grade 1, 21%-54%; grade 2, 8%-37%; grade 3, 0%-12%; grade 4, 0%).
  • The...