In the first study of its kind, cannabis oil has been shown to significantly improve the symptoms of Crohn’s disease (CD) and the quality of life of patients.
In the double-blind, placebo-controlled trial, 46 patients with active CD were randomised to receive either cannabis oil with 15 per cent cannabidiol (CBD) and 4 per cent tetrahydrocannabinol (THC) or placebo for eight weeks.
A remission rate, defined as Crohn´s disease activity index (CDAI) of less than 150, was achieved in 65 per cent of patients in the cannabis group and 35 per cent of those in the placebo group (P<.05 cannabis group also had significant improvements in quality of life compared with the placebo group. however contrary to previous medical thinking oil no effect on gut inflammation.>
Commenting on the findings, lead researcher Dr Timna Naftali said there are “good grounds” to believe that the endocannabinoid system is a potential therapeutic target in Crohn’s disease and other gastrointestinal diseases. “For now, however, we can only consider medicinal cannabis as an alternative or additional intervention that provides temporary symptom relief for some people with Crohn’s disease,” Dr Naftali said.
The findings are being presented at the United European Gastroenterology week.