- Markers of cardiac injury are prognostic for poor outcomes in COVID-19.
- High troponin I (TnI) is linked to a more than 5-fold increased risk for sever disease, ICU admission, and mortality in hospitalized patients with COVID-19, according to this meta-analysis.
Why this matters
- Because cardiac injury is now recognized as common with COVID-19, identifying related markers can be crucial for understanding which patients are at greatest risk.
- The authors say that these findings provide “some evidence for treatment guidelines.”
- Meta-analysis of 23 studies with 4631 patients.
- 16 studies had >100 patients.
- With elevated vs nonelevated TnI, relative risk (95% CIs) was increased for:
- Severe disease: 5.57 (3.04-10.22).
- ICU admission: 6.20 (2.52-15.29).
- Death: 5.64 (2.69-11.83).
- Heterogeneity among studies was fairly high.
- Elevated creatine kinase also was linked to increased risk for severe disease or ICU admission.
- New-onset arrhythmia also was an ominous sign, predicting severe disease and ICU admission.
- Elevated IL-6 was linked to increased risk for severe disease, ICU admission, and death.
- Meta-analysis of retrospective studies.
- Funding: National Key R&D Program of China.
- With attention to cardiac injury increasing only recently, some biomarker values may be underrepresented.