Takeaway
- Cardiac troponin T (cTnT) was associated with all-cause mortality in major trauma patients on admission to a UK major trauma centre critical care unit.
Why this matters
- Findings support the need for prospective verification that may suggest including cTnT into widely used major trauma risk prediction models.
Study designoponin
- Retrospective study included 243 major trauma patients (median age, 51.7 years) admitted to the intensive care unit (ICU).
- Primary outcome: all-cause mortality hospital mortality with cTnT level as the main explanatory variable.
- Funding: None.
Key results
- Of the 243 patients, 174 patients survived to hospital discharge and 69 patients died.
- cTnT level was higher in those who died compared to survivors (42 ng/L vs 13 ng/L; P<.0001).
- Risk for all-cause mortality increased with rise in cTnT level, with 53.3% dying if the cTnT level was in the highest quartile (>55 ng/L) vs 11.5% in the lowest quartile (≤7 ng/L).
- This effect was independent of age or Acute Physiology and Chronic Health Evaluation score.
Limitations
- Retrospective design.
References
References