Celiac disease is tied to increased pneumonia risk in young people

  • Dig Liv Dis

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • Young people with celiac disease (CD) have increased lifetime risk for bacterial pneumonia, especially during the year before the CD diagnosis.

Why this matters

  • The authors say that previous studies have shown increased risk for pneumococcal sepsis in pediatric or adolescent CD, up to 5 years after diagnosis in some age groups.

Key results

  • Among CD patients, risk for a first occurrence of bacterial pneumonia was increased: HR, 1.82 (95% CI, 0.98-3.35; not significant).
  • Risk was increased especially in the year before the CD diagnosis: HR, 6.00 (95% CI, 1.83-19.66).

Study design

  • Italian cohort study of 1294 CD patients matched to 6470 reference cases.
  • Funding: University of Padua.

Limitations

  • No data on several possible confounders, including socioeconomic status, smoking, current therapy.