- Carbon-ion radiotherapy (C-ion RT) with concurrent chemotherapy (chemotherapy-C-ion RT) is tied to longer survival vs C‐ion RT in patients with adenocarcinoma of the uterine cervix.
Why this matters
- Long-term efficacy of chemotherapy-C-ion RT is unknown.
- Pooled analysis of 82 patients with stage IIB-IVA adenocarcinoma of the uterine cervix who underwent C-ion RT alone or chemotherapy-C-ion RT.
- Patients received 74.4 Gy of C-ion radiation with or without weekly cisplatin.
- Funding: None disclosed.
- The matched cohort contained 26 patients who underwent C‐ion RT and 26 who underwent chemotherapy‐C‐ion RT.
- Median follow‐up duration was 34 months.
- 5‐year OS rate was significantly higher in the chemotherapy‐C‐ion RT group vs the C‐ion RT group (72% vs 46%; P=.041).
- The 5‐year distant metastatic‐free survival rate was also significantly higher in the chemotherapy‐C‐ion RT group vs the C‐ion RT group (66% vs 41%; P=.048).
- The incidence of grade ≥3 late toxicities was similar between the 2 groups (P=.602).
- Retrospective design.