CHD accelerates cognitive decline in dementia

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Takeaway 

  • In older patients with late-onset dementia, the course of cognitive decline is influenced by the presence of coronary heart disease (CHD).
  • GPs should ensure that patients with dementia receive optimal treatment for progression of arteriosclerosis.

Why this matters 

  • The effect of CHD on cognitive decline in existing Alzheimer’s disease has rarely been investigated.

Study design

  • The study included patients with mixed dementia (n=118; mean age, 85.6 [±3.4] y); presence of CHD was assessed.
  • Using Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB), cognitive performance was measured every 6 mo during a period of 3 y during h...