- A prognostic nomogram based on 5 independent factors has a C-index of 0.724 for predicting the survival of patients with de novo metastatic nasopharyngeal carcinoma (NPC).
Why this matters
- This is the first nomogram for survival of patients with de novo metastatic NPC.
- Age ≥60 years (HR, 1.58; P=.011), N stage 2-3 (HR, 1.41; P=.046), Epstein-Barr virus DNA level ≥1,000,000 (HR, 1.57; P=.030), metastatic lesion number >5 (HR, 3.89; P<.001 and multiple metastatic organs were prognostic factors in multivariate analysis.>
- A nomogram based on the above factors had C-indices of 0.724 in the primary cohort and 0.687 in the validation cohort.
- Risk groups (high, intermediate, and low) based on nomogram results were associated with OS in the primary and validation cohorts (P<.001 for both>
- 353 patients with de novo metastatic NPC were analyzed for prognostic factors to develop a nomogram, which was validated in an independent cohort of 149 patients.
- Funding: National Key R&D Program of China, National Natural Science Foundation, Sun Yat-Sen University, Guangzhou City, National Key Basic Research Program of China, Guangdong Province, National Science & Technology Pillar Program, Central Universities Fundamental Research Funds.
- Retrospective study.