Chinese study: new nomogram predicts survival of metastatic nasopharyngeal carcinoma

  • Oral Oncol

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A prognostic nomogram based on 5 independent factors has a C-index of 0.724 for predicting the survival of patients with de novo metastatic nasopharyngeal carcinoma (NPC).

Why this matters

  • This is the first nomogram for survival of patients with de novo metastatic NPC.

Key results

  • Age ≥60 years (HR, 1.58; P=.011), N stage 2-3 (HR, 1.41; P=.046), Epstein-Barr virus DNA level ≥1,000,000 (HR, 1.57; P=.030), metastatic lesion number >5 (HR, 3.89; P<.001 and multiple metastatic organs were prognostic factors in multivariate analysis.>
  • A nomogram based on the above factors had C-indices of 0.724 in the primary cohort and 0.687 in the validation cohort.
  • Risk groups (high, intermediate, and low) based on nomogram results were associated with OS in the primary and validation cohorts (P<.001 for both>

Study design

  • 353 patients with de novo metastatic NPC were analyzed for prognostic factors to develop a nomogram, which was validated in an independent cohort of 149 patients.
  • Funding: National Key R&D Program of China, National Natural Science Foundation, Sun Yat-Sen University, Guangzhou City, National Key Basic Research Program of China, Guangdong Province, National Science & Technology Pillar Program, Central Universities Fundamental Research Funds.

Limitations

  • Retrospective study.