Takeaway
- Low 25-hydroxyvitamin D (25[OH]D) level is associated with increased mortality in patients with chronic heart failure (CHF) because of left ventricular systolic dysfunction.
Why this matters
- Low 25[OH]D levels have been associated with adverse outcomes, especially in patients with suspected coronary artery disease, hypertension, and CHF.
- However, there is no clarity whether 25[OH]D deficiency independently predicts outcomes in unselected patients with CHF.
Study design
- Study prospectively evaluated prevalence and correlation of 25[OH]D deficiency with hospitalisation and mortality in 1802 patients with CHF.
- Funding: The British Heart Foundation.
Key results
- Of 1802 patients recruited, 914 (73%) were 25[OH]D (<50 nmol/L) deficient.
- During a mean 4 years of follow-up, each 2.72-fold increment in 25[OH]D level was associated with a 14% lower risk for all-cause mortality (HR, 0.86; P=.042) after adjustment for confounders.
- Adjusted survival curves according to 25[OH]D status, 25[OH]D deficiency was associated with increased mortality risk (HR, 1.24, 95% CI, 1.05-1.46)
Limitations
- Study did not consider all relevant confounders.
- Blood samples of 25[OH]D across centres were not standardised.
References
References
