Chronic urticaria tied to higher risk for osteoporosis

  • Shalom G & al.
  • Br J Dermatol
  • 18 Dec 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A nationwide cohort study from Israel suggests that chronic urticaria (CU) is associated with an increased risk for osteoporosis.

Why this matters

  • Findings suggest that early screening is warranted.

Key results

  • Incidence of osteoporosis was 12.26 per 1000 person-years in patients with CU and 9.31 per 1000 person-years in control patients.
  • CU was associated with increased risk for osteoporosis (HR, 1.225; P<.001>
  • Age (HR, 1.067; P<.001 corticosteroid use smoking and hypothyroidism were also associated with increased osteoporosis risk whereas male sex obesity decreased risk.>
  • In a subgroup analysis of patients without exposure to systemic corticosteroids, CU was associated with increased risk for osteoporosis (HR, 1.44; P<.001>

Study design

  • 11,944 patients with CU and 59,829 control patients from the Clalit Health Services database were analyzed for osteoporosis incidence.
  • Funding: None.

Limitations

  • Observational study of large database.

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