Classic PTC tied to poorer long-term outcomes than follicular variant

  • Henke LE & al.
  • Endocr Connect
  • 1 Oct 2018

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • A single-center, retrospective study suggests that classic papillary thyroid carcinoma (C-PTC) is associated with worse recurrence-free survival (RFS) and disease-specific survival (DSS) compared with follicular variant (FV)-PTC.

Why this matters

  • This study lends further support to recent data suggesting that C-PTC leads to worse outcomes.

Key results

  • Mean follow-up, 8.6 years.
  • C-PTC was associated with features of high-risk disease:
    • Thyroid capsule invasion (P<.001>
    • Soft tissue invasion (P<.001>
    • Positive surgical margins (P=.013).
    • Cervical lymph node metastasis (P≤.001).
  • C-PTC was associated with reduced RFS (P<.001 and dss compared with fv-ptc. style="list-style-type:circle;">
  • In multivariate analysis, risk for recurrence was significantly associated with C-PTC (HR, 2.0; P<.001>
  • Although BRAF mutations were more common in patients with C-PTC (P=.002), mutational status was not associated with RFS (P=.594) or DSS (P=.182).
  • Study design

    • 1293 patients with invasive PTC (74% with C-PTC and 26% with FV-PTC) who underwent partial or total thyroidectomy were analyzed for outcomes (542 underwent BRAF analysis).
    • Funding: National Center for Advancing Translational Sciences.

    Limitations

    • Retrospective study.

    Please confirm your acceptance

    To gain full access to GPnotebook please confirm:

    By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

    Submit