- A single-center, retrospective study suggests that classic papillary thyroid carcinoma (C-PTC) is associated with worse recurrence-free survival (RFS) and disease-specific survival (DSS) compared with follicular variant (FV)-PTC.
Why this matters
- This study lends further support to recent data suggesting that C-PTC leads to worse outcomes.
- Mean follow-up, 8.6 years.
- C-PTC was associated with features of high-risk disease:
- Thyroid capsule invasion (P<.001>
- Soft tissue invasion (P<.001>
- Positive surgical margins (P=.013).
- Cervical lymph node metastasis (P≤.001).
- 1293 patients with invasive PTC (74% with C-PTC and 26% with FV-PTC) who underwent partial or total thyroidectomy were analyzed for outcomes (542 underwent BRAF analysis).
- Funding: National Center for Advancing Translational Sciences.
- Retrospective study.