- Many first-degree relatives (FDRs) of patients with coeliac disease are also affected, but are either asymptomatic or have apparently unrelated symptoms.
Why this matters
- The authors suggest that all patients who have parents, siblings, or children with coeliac disease should be screened.
- Researchers analysed the health records of 104 patients with coeliac disease (mean age, 30.8±19.7 years; 61.5% women) and 360 FDRs (mean age, 31.9±21.6 years; 62% women) for presenting symptoms, biopsy reports, and serologic test results.
- Funding: None disclosed.
- After screening, 160 FDRs (44.4%) were diagnosed with coeliac disease.
- Of 148 FDRs with documented clinical features, 6.1% had classic coeliac symptoms, 65.5% had nonclassic symptoms, and 28.4% had no reported symptoms.
- Of 155 FDRs with available histology reports, 7.7% had a Marsh 1 classification, 49.7% had Marsh 3a, and 42.6% had Marsh 3b.
- The study was retrospective and subject to referral bias.