Cognitive impairment linked to carotid atherosclerosis in the very old
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Carotid atherosclerosis is consistently linked to cognitive impairment in the very old and affects the association with latent cytomegalovirus infection (CMV) infection.
In the Tokyo Oldest Old Survey on Total Health, 494 community-dwelling participants 85 years without baseline dementia underwent Mini-Mental State Examination (MMSE) and other testing at baseline and 3-year follow-up.
Mean MMSE scores were 1.08 points lower in persons with high carotid artery ultrasound plaque score (≥5.0) than in those without plaque (95%CI -1.95 to -0.20; P=.016), adjusted for age, sex, and education.
MMSE scores were 1.47 points lower In persons with CMV IgG titers in the highest vs. lowest quartile (-2.44 to -0.50; P=.003).