Colorectal cancer: higher post-operative vitamin D level tied to better survival

  • Markotic A & al.
  • Nutr Cancer
  • 4 Apr 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Higher post-operative 25-hydroxyvitamin D (25-OHD) levels are associated with better overall survival (OS) in patients with colorectal cancer (CRC).
  • No association was observed between pre-operative 25-OHD levels and OS.

Why this matters

  • Vitamin D may help to predict survival outcome in CRC.
  • Currently, it is unclear what is the most valuable timepoint of blood sampling to determine the association of vitamin D with survival in CRC.

Study designs

  • Study included 515 patients with CRC American Joint Committee on Cancer (AJCC) stages I-III who underwent surgery.
  • Patients were divided into pre-operative (n=286; 1 day before surgery) and post-operative (n=229; 8 days after surgery) cohorts according to the time when blood samples were collected for 25-OHD measurement.
  • Funding: Cancer Research UK.

Key results

  • Among 515 patients with CRC, median 25-OHD concentration was 36.7 (interquartile range [IQR], 21.0-55.5) nmoL/L and follow-up duration was 5.9 (IQR, 4.9-6.8) years.
  • Overall median survival time for patients who died during follow-up was 2.4 (IQR, 1.1-3.7) years, and for stages I-III was 3.5 (IQR, 2.8-4.7), 2.5 (IQR, 1.1-3.8) and 1.9 (IQR, 1.1-3.3) years, respectively.
  • Pre- vs post-operative cohorts did not differ in age, sex, 25-OHD, AJCC stage and localisation of tumour.
  • After adjustment for confounders, higher post-operative 25-OHD (>50 nmol/L) level was associated with better OS (HR, 0.53; P=.006), but not pre-operative 25-OHD level (HR, 1.11; P=.646).

Limitations

  • Study evaluated only OS of patients with CRC.