Congenital hypothyroidism in infants: which factors predict permanent disease?

  • Park ES & al.
  • BMC Pediatr
  • 22 Nov 2019

  • International Clinical Digest
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Takeaway

  • High levothyroxine dose at discontinuation is associated with permanent hypothyroidism in infants with congenital hypothyroidism.

Why this matters

  • Risk factors for permanent hypothyroidism are poorly understood in this patient population.

Key results

  • 11.3% of patients experienced permanent hypothyroidism (failure following levothyroxine discontinuation).
  • 88.8% of patients experienced transient hypothyroidism (successfully discontinued levothyroxine).
  • Higher levothyroxine dose at discontinuation was associated with increased risk of permanent hypothyroidism (OR, 3.443; P=.009).
  • A levothyroxine dose of 2.86 μg/kg had 88.9% sensitivity, 71.0% specificity, and area under the receiver operating characteristic curve of 0.849 for predicting treatment failure.

Study design

  • 80 infants with congenital hypothyroidism were included.
  • Funding: None.

Limitations

  • Retrospective study.

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