COPD: influenza vaccine cuts influenza-related hospitalization

  • Mulpuru S & al.
  • Chest
  • 1 Jan 2019

  • curated by Liz Scherer
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.


  • Seasonal influenza vaccination significantly reduces influenza-related hospitalizations by 38% in patients with COPD.

Why this matters

  • Ensure that patients with COPD receive age-appropriate quadrivalent or recombinant influenza vaccines per updated CDC guidelines.
  • Consider antivirals in hospitalized patients to reduce influenza-related complications.

Key results

  • 4755 hospitalized patients with COPD; 38.5% (1833) with PCR-confirmed influenza.
  • 41% (612/1490) of influenza patients had not been vaccinated during season when hospitalization occurred, 69.3% received antivirals while hospitalized.
  • 9.7% (177/1833) influenza-positive patients required mechanical ventilation, 11.1% (204/1833) died, 18.1% (332/1833) admitted to intensive care.
  • Risk factors for mechanical ventilation: diabetes (OR, 1.7; 95% CI, 1.1-2.6), current smoking (OR, 3.2; 95% CI, 1.5-7.2).
  • Risk factors for mortality (hospitalized patients): age >75 years (OR, 3.7; 95% CI, 0.4-30.3), home oxygen use (OR, 2.9; 95% CI, 1.6-5.1), admission from long-term care (OR, 2.6; 95% CI, 1.5-4.5).

Study design

  • Post hoc analysis of prospective cohort study data to determine influenza vaccine effectiveness for preventing influenza-related hospitalization in patients with COPD.
  • Funding: Canadian Institutes for Health Research, others.


  • Noninfluenza virus rates unconfirmed.
  • COPD cases confirmed by medical records.
  • Selection bias.
  • Unaccounted bacterial co-infections, frailty selection bias, all-cause mortality.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.