- Among patients hospitalized with COVID-19, the pulmonary embolism (PE) prevalence is 1 in 20.
- In cases of CT for clinical suspicion for PE, PE prevalence is about 1 in 5.
Why this matters
- PE is common with COVID-19 pneumonia.
- ICU patients with COVID-19 have especially high PE risk.
- PE and extension of COVID-19 lesions correlate on CT.
- 1042 patients with COVID-19.
- 25.8% had CT pulmonary angiography.
- PE prevalence:
- 5.6% overall.
- 21.2% among those having CT.
- Need for invasive mechanical ventilation was linked to increased PE risk:
- OR: 2.79 (95% CI, 1.33-5.84).
- 20.3% with PE vs 16.1% without PE on CT.
- OR: 1.36 (95% CI, 0.53-3.14).
- PE was linked to more extensive COVID-19 lesions on CT vs no PE on CT:
- OR: 3.9 (95% CI, 1.54-9.94).
- Also linked to parenchymal lesions >50%.
- Patients with PE had greater odds of having elevated C-reactive protein:
- OR: 3.36 (95% CI, 1.58-7.14).
- PE risk was 5.11-fold higher with D-dimer >2605 ng/mL (95% CI, 1.90-13.76).
- Retrospective, multicentric case-control series evaluating PE prevalence, characteristics in consecutive French patients hospitalized with COVID-19 pneumonia; 2 French hospitals.
- Funding: None disclosed.
- Immortal time bias.
- Inconsistent CT investigations.