- Among patients in Wuhan, China, who are critically ill with novel coronavirus (COVID-19)-associated pneumonia, mortality exceeds 50%.
- Older men are especially vulnerable, at least in this region.
- Serial radiographic examinations may be useful.
- Fever is sometimes delayed.
Why this matters
- As COVID-19 spreads, information on clinical manifestations is urgently needed.
- Mean age: 59.7 years; 67% men.
- 98% had fever, but it was not detected in 11.5% until 2-8 days after illness onset.
- Median duration from symptom onset to:
- Radiological confirmation of pneumonia: 5 days.
- ICU admission: 9.5 days.
- 71% required mechanical ventilation.
- 85% showed lymphocytopenia.
- Organ damage incidence:
- Acute respiratory distress syndrome (ARDS): 67%.
- Acute kidney injury: 29%.
- Cardiac injury: 23%; median high-sensitivity troponin I: 161.0 (interquartile range, 41.8-766.1) pg/mL.
- Liver dysfunction: 29%.
- Hospital-acquired infection: 13.5%.
- 28-day mortality: 61.5%.
- Median survival duration after ICU admission: 7 days.
- Compared with survivors, nonsurvivor group was older and had higher rates of chronic illness, ARDS, and mechanical ventilation requirement.
- Single-center retrospective observational study (n=52).
- Researchers assessed adults with COVID-19 pneumonia in dedicated Wuhan ICU from December 24, 2019 to January 26, 2020.
- Outcome: 28-day mortality following ICU admission.
- Funding: None.
- Must be considered exploratory.