- SARS-CoV-2 infections in children were occurring early in the epidemic, according to retrospective data in a small number of COVID-19 cases in Wuhan, China.
Why this matters
- Despite limited case data describing COVID-19 clinical characteristics and disease spectrum in children, evidence suggests that infections may cause moderate-to-severe respiratory illnesses in some but that recovery is likely.
- 366 hospitalized children.
- Most frequently detected pathogens: influenza A (6.3%, n=23), influenza B (5.5%, n=20), and SARS-CoV-2 (1.6%, n=6).
- COVID-19 patients (n=6):
- Median age, 3 years (range 1-7).
- Illness onset: January 2-8, 2020.
- Hospitalizations: January 7-13, 2020.
- Most common clinical characteristics: high fever (>39℃, all), cough (all), vomiting (n=4).
- Labs: below normal lymphocytes (all), low white cells (n=4), low neutrophils (n=3).
- Pneumonia (n=4), with patchy ground glass opacities (both lungs, n=1) or patchy shadows (both lungs, n=3) on CT.
- 1 patient admitted to ICU and administered pooled immunoglobulins; all patients received empirical antivirals, antibiotics, supportive therapy.
- 100% recovery, post-hospitalization (median, 7.5 [5-13] days).
- No patients, family members had Wuhan market contact.
- Retrospective case analysis of respiratory infections in hospitalized, Chinese children (aged ≤16 years old), 7-15 January, 2020.
- Funding: Ministry of Science and Technology of China.
- Small case numbers.