- A Surveillance, Epidemiology, and End Results (SEER) database analysis shows a steep increase in colorectal cancer (CRC) incidence from age 49 to 50 years.
Why this matters
- Previous age-block analyses missed the increase.
- There may be a high case burden of preclinical, undetected early-onset CRC among younger individuals.
- Retrospective analysis of 1-year age intervals (span, 30-60 years) of the SEER database (n=165,160 CRC cases; 55.9% men; 75.4% white).
- Funding: None disclosed.
- The largest increase in CRC incidence across any age transition was found between ages 49 and 50 years:
- Rate ratio incidence, 1.46 (95% CI, 1.43-1.51).
- Log-linear modeling suggested that advancing age would account for a 16.6% increase.
- The age 49-50 years increase was found in all regions of the United States in both men and women, in white and black populations, and in both colon and rectal cancers.
- The increase was seen for localized-stage disease (75.9% increase), regional-stage disease (30.3%), and distant-stage disease (15.7%).
- Of CRCs diagnosed in patients aged 50 years, 92.9% were invasive.
- Retrospective analysis.