- Older adults seropositive for Borrelia burgdorferi did not have higher risk for dementia, or higher levels of depression or functional decline.
Why this matters
- Studies potentially implicating this pathogen have had various shortcomings.
- Baseline seroprevalence of B burgdorferi: 6.5%.
- Relative to seronegative counterparts, seropositive participants:
- Were older (mean, 77.8 vs 75.7 years; P=.02),
- Were more often male (86.7% vs 61.0%; P<.010 and>
- Had lower Center for Epidemiologic Studies Depression scale scores (mean, 2.6 vs 4.6; P<.010>
- French prospective cohort study of 689 retired male and female farmers who were aged ≥65 years and agreed to provide a blood sample (Aging Multidisciplinary Investigation study).
- Main outcomes: cognitive decline, incident dementia, depressive symptoms, and functional decline at 6-year follow-up.
- Funding: AGRICA; Mutualité Sociale Agricole de Gironde; Caisse Centrale de la MSA.
- Lack of data on B burgdorferi exposure, course.
- Small number of seropositive participants.
- Limited duration of follow-up.
- Unknown generalisability.