Depression may be causally linked with risk of T2D and CAD

  • Tang B & al.
  • Diabetologia
  • 8 Apr 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Genetic liability to major depressive disorder (MDD) was significantly associated with an increased risk of type 2 diabetes (T2D) and coronary artery disease (CAD).
  • Liability to T2D, CAD, and heart failure (HF) was not related to MDD in the reverse Mendelian randomisation (MR) analysis.

Why this matter

  • Findings strengthen the casual inference that depression is a potential casual risk factor for T2D and CAD.

Study design

  • This bidirectional MR study used summary-level data from meta analyses of genome-wide association studies of MDD, T2D, CAD, and HF, mainly of European ancestry.
  • 96 single-nucleotide polymorphisms for MDD, 202 for T2D, 44 for CAD, and 12 for HF reached genome-wide significance and were used as instrumental variables.
  • Funding: Uppsala University.

Key results

  • The OR of T2D per one-unit increase in loge odds of MDD liability was 1.26 (95% CI, 1.10-1.43).
  • The ORs per one-unit increase in loge odds of MDD liability for CAD and heart failure were 1.16 (95% CI, 1.05-1.29) and 1.11 (95% CI, 1.01-1.21), respectively.
  • There was limited evidence supporting any causal association in the reverse direction.

Limitations

  • Potential risk of pleiotropy.
  • Population stratification may have affected the result for the association between CAD and MDD.