Depression tied to dementia risk in patients with lower urinary tract symptoms

  • Ou MJ & al.
  • PLoS ONE
  • 1 Jan 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • In patients with lower urinary tract symptoms (LUTS), depression was associated with increased risk for dementia.
  • Findings suggest that early screening and interventions may be important to maintain cognitive function in these patients.

Why this matters

  • LUTS are reported to be independently linked with depression and dementia. However, the association between depression and cognitive dysfunction in patients with LUTS is not properly defined.

Study design

  • Matched cohort study of 15,944 patients with LUTS (age, ≥50 years).
  • Cases developed depression subsequently (n=1958).
  • Controls included patients without depression after matching with confounding factors (n=7832).
  • Primary outcome: first onset of dementia.
  • Funding: Kaohsiung Medical University Hospital.

Key results

  • Among patients with LUTS, crude incidence of depression was 12.3%.
  • The proportion of patients who developed dementia was significantly higher in the depression group vs the control group (12.2% vs 8.9%; P<.001>
  • After adjustment for confounders, depression was associated with a significantly higher risk for subsequent dementia (HR, 1.32; 95% CI, 1.13-1.54).

Limitations

  • Duration and cumulative dose of antidepressants not evaluated, and this affects further dementia prevalence.

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