- A population-based nationwide cohort finds that depression increases the risk for incident hip fracture by 46% in patients ≥50 years, after adjustment for many factors including past medical history.
Why this matters
- Relationship may be mediated by higher cortisol-induced lowering of bone mineral density.
- One of the first studies to control for past medical history (hypertension, diabetes, and dyslipidemia).
- Findings suggest that treating depression has the potential to reduce hip fracture risk.
- Retrospective, population-based nationwide cohort from the Korean National Health Insurance Service-National Sample Cohort.
- Patients with depression (≥50 years of age; years 2002-2013; n=25,197) were matched to 100,788 control patients matched for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia.
- Funding: National Research Foundation of Korea.
- Across the whole cohort, people with depression were at 46% increased risk for hip fracture (1.1% vs 0.7% in control patients; aHR, 1.46; P<.001>
- Subgroup analysis found increased risk in old men (≥65 years; aHR, 1.40; P=.047).
- Subgroup analysis found increased risk in old women (≥65 years; aHR, 1.60; P<.001>
- Observational design.
- Severity of disease and treatment histories could not be ascertained.