- Urine test (CRD Paper Test) shows promise in correctly diagnosing preeclampsia (PE).
Why this matters
- 70,000 women die each year from PE.
- Misfolded proteins have been identified in the urine of women with PE.
- These proteins have an affinity toward the azo-dye Congo Red (congophilia).
- Spot test can save time and may prevent misdiagnosis.
- Urine congophilia was detected in 12% of patients with an uncertain diagnosis and 58% with a diagnosis of PE.
- CRD Paper Test to confirm and rule out PE was more accurate compared with all other serum biomarkers.
- A positive CRD Paper Test correctly diagnosed PE:
- 80.2% sensitivity,
- 89.2% specificity,
- 92.1% negative predictive value, and
- 86.7% accuracy.
- Simple bedside, paper-based CRD Paper Test compared with routine assessment for PE.
- Main outcome: area under the curve to confirm and rule out PE.
- Consecutive pregnant patients presenting for evaluation for PE (n=353) included.
- CRD Paper Test administered; clinical team blinded to results.
- Medical decisions based only on clinical findings.
- Funding: USAID; SLaB; Bill and Melinda Gates Foundation; NIH; others.
- Further validation studies needed.