- Postmenopausal women with a total magnesium intake between the estimated average requirement and recommended dietary allowances (257.3-317.8 mg/day) had reduced risks for mild cognitive impairment (MCI) alone and for the composite of MCI and probable dementia.
Why this matters
- Attractiveness of lifestyle modification to reduce risk.
- 11.8% of women developed MCI and/or probable dementia during >20 years of follow-up.
- In multivariate analysis, compared with quintile 1 of magnesium intake, risk for MCI alone significantly lower for:
- Quintile 3 (HR, 0.63; 95% CI, 0.45-0.87).
- Quintile 4 (HR, 0.67; 95% CI, 0.46-0.97).
- Quintile 5 (HR, 0.61; 95% CI, 0.39-0.96).
- Risk for MCI/probable dementia significantly lower for quintile 3 (HR, 0.69; 95% CI, 0.53-0.91).
- No significant associations observed for probable dementia alone.
- Prospective cohort study of 6473 postmenopausal women aged 65-79 years without dementia (Women’s Health Initiative Memory Study).
- Main outcomes: physician-adjudicated MCI and/or probable dementia.
- Funding: National Heart, Lung, and Blood Institute, National Institutes of Health; US Department of Health and Human Services; Wyeth Pharmaceuticals; National Institute on Aging.
- Magnesium intake assessed at baseline only.
- Lack of information on serum levels.
- Intake via standard multivitamins not assessed.
- Residual confounding.
- Unknown generalisability.