- A low proportion of tumor-infiltrating T lymphocytes (TIL-Ts) and a high ratio of CD4:CD8 ratio of TIL-Ts within the tumor microenvironment may identify a subset patient with de novo diffuse large B-cell lymphoma (DLBCL) at higher risk of inferior survival.
Why this matters
- Few DLBCL studies have focused on the prognostic role of TIL-Ts within the tumor microenvironment.
- Study to investigate an association between TIL-Ts as a proportion of the tumor microenvironment and outcomes in 66 patients with de novo DLBCL.
- 61 (range, 8-83) years median patient age.
- Funding: National Natural Science Foundation of China, Sichuan Science and Technology Program.
- In multivariate analysis, the following were independent risk factors for inferior survival:
- Low TIL-T proportion (
- High CD4:CD8 ratio (≥1.2 vs
- In risk analysis, patients were stratified into 3 groups; patients in the high-risk group (low TIL-Ts, high CD4:CD8 ratio) demonstrated inferior survival vs:
- Intermediate-risk patients (low TIL-Ts, low CD4:CD8 or high TIL-Ts, high CD4:CD8): P=.025.
- Low-risk patients (high TIL-Ts, low CD4:CD8 ratio): P=.002.
- Retrospective data.