Do antiepileptic drugs raise the risk for suicide attempts?
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In patients with a lifetime history of depression or no neurological conditions, the association observed between antiepileptic drug (AED) use and increased odds of non-fatal suicide attempts (SA) may be explained by the presence of underlying psychiatric disorders.
Why this matters
Several retrospective studies evaluating the association of AED use and risk of SA have provided conflicting results.
This case-control study compared the use of AED in patients who attempted suicide (n=506) and those who did not (n=2829).
The primary outcome was non-fatal SA in the last 30 d.