Do antiepileptic drugs raise the risk for suicide attempts?

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Takeaway 

  • In patients with a lifetime history of depression or no neurological conditions, the association observed between antiepileptic drug (AED) use and increased odds of non-fatal suicide attempts (SA) may be explained by the presence of underlying psychiatric disorders.

 Why this matters 

  • Several retrospective studies evaluating the association of AED use and risk of SA have provided conflicting results.

Study design

  • This case-control study compared the use of AED in patients who attempted suicide (n=506) and those who did not (n=2829).
  • The primary outcome was non-fatal SA in the last 30 d.
  • Funding: Not disclosed.

  Key results

  • AED use in the 12 mo ...