Do statins work similarly for patients with severe mental illness?

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  • Statin prescribing to patients with severe mental illness (SMI) was associated with similar level of benefit to the general population with observed reductions for total cholesterol of 1.2 mmol/L up to 2 y.
  • This suggests that medication adherence is sufficient for effective lipid modifications.

Why this matters

  • Compared with patients without SMI, those with SMI including schizophrenia and bipolar disorder are at a higher risk for cardiovascular disease.

Study design

  • Study included patients diagnosed with SMI (age, 40-84 y) who were exposed to 1 or more statin prescription during a 24-mo ‘baseline’ period.
  • Primary outcome was combined first myocardial infarction (MI) and stroke; secondary outcome included all-cause mortality and total cholesterol concentration.
  • Funding: NIHR.

Key results

  • 2944 statin ...