Does decaffeinated coffee intake improve insulin sensitivity?

  • Reis CEG & al.
  • Br J Nutr
  • 8 Mar 2018

  • from Sarfaroj Khan
  • Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Consumption of decaffeinated coffee showed significant improvement in insulin sensitivity without changing incretin hormones levels in the short-term.
  • Consumption of coffee with sugar showed no effect on glucose, insulin, C-peptide and incretin hormones, compared with water with sugar.

Why this matters

  • According to several epidemiological studies, coffee consumption is beneficial and inversely associated with the risk of developing chronic diseases.
  • Several prospective studies have reported a negative association between high coffee consumption and risk for type 2 diabetes mellitus.

Study design

  • Randomised, cross-over, single-blind study of 17 healthy men who consumed either coffee or water during the trial and were subjected to oral glucose tolerance test.
  • Funding: National Council for Scientific and Technological Development, MRC-Elsie Widdowson Laboratory.

Key results

  • At the beginning of each experiment, no significant difference in body weight (P=.99), capillary glucose (P=.97) or number of hours slept (P=.66) was observed.
  • Significant increase in insulin sensitivity (97.5%) was seen in patients consuming decaffeinated coffee vs water (P<.05>
  • Glucose effectiveness was higher in participants consuming regular coffee with or without sugar vs water (P=.07).
  • Participants consuming regular coffee with sugar showed no significant change in effect on glucose, insulin, C-peptide and incretin hormones.

Limitations

  • Small sample size.