- Moderate-to-vigorous-intensity physical activity (MVPA) and BMI are independently associated with glycated haemoglobin (HbA1c).
- The association of MVPA with HbA1c is stronger in people with higher BMI levels.
Why this matters
- The effects of physical activity and weight loss on HbA1c are well defined in populations with diabetes, however, they are less clear in populations without diabetes.
- Every 30 min/day increment in MVPA was associated with a 0.7 mmol/mol (0.07% (P<.001)) lower HbA1c level.
- Each 1 kg/m2 increment in BMI was associated with a 0.2 mmol/mol (0.02% (P<.001)) higher HbA1c level.
- The association of MVPA with HbA1c was stronger in obese individuals (-1.5 mmol/mol (-0.13% (P<.001))) than non-obese individuals (-0.7 mmol/mol (-0.06% (P<.001))); P=.004 for interaction.
- The association of BMI with HbA1c remained stable across MVPA categories.
- This study used 2008 Health Survey for England data to evaluate the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and BMI with glycated haemoglobin (HbA1c) in 1109 participants (age ≥18 y).
- MVPA was measured using an ActiGraph GT1M accelerometer.
- Funding: UK Research Councils’ Lifelong Health and Wellbeing Initiative.
- Cross-sectional design.