- High or no coffee intake is linked to a modestly increased cardiovascular disease (CVD) risk, but the genetic variants associated with caffeine metabolism appear to have no role.
Why this matters
- Almost every adult in the world seems to drink coffee, but some studies have linked intake, myocardial infarction/hypertension risk, and specific genetic variants associated with slow caffeine metabolism.
- Compared with people who had 1-2 cups/day, people who drank no coffee, decaf coffee, or >6 cups of coffee/day had CVD odds increased by 11%, 7%, and 22%, respectively.
- Having the slow caffeine metabolizer genotype had no effect on risk.
- UK Biobank genetic data for 347,077 people.
- Regressed for associated coffee intake, CVD risk, any variation with metabolizer genotype.
- Funding: JJ Mason and HS Williams Memorial Foundation, National Health and Medical Research Council, Australia.
- Biobank data do not represent general population.
- Generalizability not known.