Drivers of desired complete clearance in psoriasis, atopic dermatitis

  • Egeberg A & al.
  • J Am Acad Dermatol
  • 13 Jun 2019

  • International Clinical Digest
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Takeaway

  • Disease severity, symptoms, and anatomic site are associated with importance of complete or almost-complete skin clearance in patients with psoriasis or atopic dermatitis (AD).

Why this matters

  • Patient-reported importance of skin clearance may affect treatment strategies.

Key results

  • 71.7% of patients with psoriasis and 81.5% of patients with AD reported a numerical rating scale (NRS) score of ≥8 for importance of almost-complete skin clearance.
    • 60.0% and 65.9%, respectively, for complete skin clearance.
  • Disease severity, itch severity, and skin pain were associated with higher importance of almost-complete and complete skin clearance for both diseases (P<.0001 for all>
  • In patients with AD, face or neck site was associated with importance of almost-complete skin clearance (P<.0001>
  • In patients with psoriasis, face, neck, palm, sole, or genital site was associated with importance of almost-complete skin clearance, whereas palm or sole site was associated with importance of complete skin clearance (P<.05 for all>
  • 7% of patients with severe AD and 27% of patients with severe psoriasis were receiving systemic therapy.

Study design

  • 4016 patients with psoriasis and 3842 patients with AD were included.
  • Funding: Danish Psoriasis Foundation.

Limitations

  • Specific reasons for infrequent use of systemic treatments not examined.

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