Early infection or antibiotic use tied to coeliac disease risk

  • Jiang HY & al.
  • J Gastroenterol Hepatol
  • 16 Nov 2019

  • curated by Pavankumar Kamat
  • UK Medical News
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A recent meta-analysis published in the Journal of Gastroenterology and Hepatology suggests that exposure to infection or antibiotic in early life can increase the odds of developing coeliac disease (CD) later on.

Researchers conducted a meta-analysis of 19 observational studies (15 on infection and six on antibiotic exposure) identified through a literature search on PubMed and Embase databases.

The pooled analysis of 15 studies showed that any infection in early life was associated with an increased risk of CD later in life (OR, 1.37; 95% CI, 1.2-1.56; P<.001 in subgroup analyses the type of infectious agent timing exposure and site infection did not alter association between cd risk. additionally to antibiotics had an with new-onset ci p>

According to the authors, "dysbiosis of the gut microbiota induced by infection or associated antibiotic use may be a risk factor for CD." They call for future research through large prospective cohort studies to establish the causality within the observed association.