- This meta-analysis suggests that early menopause (EM, age at menopause 45 or >50 years, without any distinct effect on the site of the fracture.
- No such association is observed between premature ovarian insufficiency (POI) and fracture risk.
Why this matters
- EM and POI are associated with an increased risk for osteoporosis. However, their association with increased fracture risk has not been established and studies evaluating their association have yielded conflicting results.
- Meta-analysis of 18 studies involving 462,393 postmenopausal women and 12,130 fractures evaluated the association between age at menopause and fracture risk.
- Funding: None disclosed.
- Women with EM had a higher risk for fracture vs those of age at menopause >45 years (OR, 1.36; 95% CI, 1.11-1.66; P<.002>
- No difference in fracture risk was observed between women with POI and those of age at menopause >40 years (OR, 1.23; 95% CI, 0.72-2.09; P=.436) or >45 years (OR, 0.54; 95% CI, 0.22-1.29; P=.170).
- Separate analysis demonstrated no difference with respect to nonvertebral (OR, 1.66; 95% CI, 0.79-3.5; P=.177), vertebral (OR, 1.09; 95% CI, 0.87-1.37; P=.443) and hip fractures (OR, 1.18; 95% CI, 0.95-1.46; P=.120).
- Heterogeneity among included studies.