- Revision of initially positive surgical margins based on frozen section analysis fails to improve locoregional recurrence-free survival (LRFS) in early oral cavity cancer (OCC), according to a systematic review and meta-analysis.
Why this matters
- Current practice is to use margins from intraoperative frozen sections to guide the need for further resection.
- Patients with positive/close margins that were cleared with further resection had lower LRFS than those with initially negative margins (HR, 2.592; P<.001 style="list-style-type:circle;">
- HR, 2.575; P=.014 in patients with tongue cancer.
- HR, 3.439; P=.001 in patients with floor of mouth cancer.
- HR, 2.278; P=.025 in patients with other OCC sites.
- 8 studies involving 1427 patients with OCC were included in the meta-analysis.
- Study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) system.
- Funding: None.
- Retrospective studies.