- An electronically delivered cognitive behavioral therapy (CBT; Emyna) tailored to the needs of people with epilepsy alleviated symptoms of depression.
Why this matters
- Depression and anxiety occur in up to 28% and 26% of people with epilepsy, respectively, but often go underrecognized and undertreated.
- In intention-to-treat analyses at 3 months, benefit of intervention over usual care:
- Patient Health Questionnaire-9 (Cohen d, 0.54; P<.001>
- Neurological Disorders Depression Inventory for Epilepsy (Cohen d, 0.51; P<.001>
- Illness-related days off work (8.56 vs 16.02; P=.040).
- Days hospitalized over the preceding 3 months (1.67 vs 3.88; P=.031).
- Randomized controlled ENCODE trial among 200 patients with epilepsy and depressive disorder, with at least moderate depressive symptoms.
- Randomization: intervention vs usual care.
- Intervention: 6 months of access to electronically delivered, epilepsy-tailored CBT with content on depression, stress, anxiety, seizure triggers, auras, lifestyle habits.
- Main outcome: depressive symptoms at 3 months.
- Funding: Gaia Group.
- Dropout rate of 23%.
- Reliance on self‐reported measures.
- Lack of active control.
- 9‐month assessment taking place only 3 months after end of program access.