- Sentinel node mapping is noninferior to lymphadenectomy with respect to detection of paraaortic nodal involvement and recurrence rates.
- Sentinel node mapping may offer better detection of positive pelvic nodes.
Why this matters
- National Comprehensive Cancer Network guidelines approved sentinel node mapping for endometrial cancer staging procedures in endometrial cancer.
- Although findings support noninferiority of sentinel node mapping, prospective validation is needed.
- Meta-analysis of 6 studies including 3536 patients with endometrial cancer.
- 35.3% of patients underwent sentinel node mapping, and 64.7% had lymphadenectomy.
- Funding: None.
- Positive pelvic nodes were detected in 14.7% of patients undergoing sentinel node mapping vs 9.9% of those having lymphadenectomy (OR, 2.03; P=.002).
- Low-risk patients: OR, 3.12 (P=.01).
- Intermediate-/high-risk patients: OR, 2.04 (P=.009).
- No significant difference was observed in para-aortic node detection rate between patients who received sentinel node mapping vs lymphadenectomy (OR, 0.93; P=.86).
- Overall recurrence rate was similar with sentinel node mapping and lymphadenectomy (4.3% vs 7.3%; OR, 0.90; P=.63).
- Nodal recurrence rates were similar between groups (1.2% vs 1.7%; OR, 1.51; P=.29).
- Retrospective studies were included.