Fasting insulin is the best predictor of pediatric NAFLD

  • Prokopowicz Z & al.
  • Can J Gastroenterol Hepatol
  • 1 Jan 2018

  • curated by Craig Hicks
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Fasting insulin >18.9 μIU/mL is the best independent predictive factor for nonalcoholic fatty liver disease (NAFLD) in obese children.

Why this matters

  • "[NAFLD] is the most common cause of chronic liver disease in obese children," say researchers. "Early diagnosis and treatment are essential for curing or slowing down the disease progression."

Study design

  • Researchers studied obese pediatric patients both with and without NAFLD (n=108; age range, 6 years+2 months to 17 years+10 months; 50 boys).
  • They assessed patient anthropometric measurements, NAFLD diagnosis, and metabolic syndrome (MS) components.
  • Funding: Medical University of Silesia.

Key results

  • NAFLD diagnosis rate was 45.4% (n=49) overall, with similar prevalence in boys (55.1%; n=27) and girls (44.9%; n=22; P=.089).
  • MS was more likely in patients with NAFLD (40.82% vs 23.73%; P=.04).
  • Researchers found that fasting insulin concentration with a cutoff point of 18.9 μIU/mL (area under the curve, 0.829) was the best independent predictor of NAFLD.

Limitations

  • The study was single-center with a small sample size.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit