- Fasting insulin >18.9 μIU/mL is the best independent predictive factor for nonalcoholic fatty liver disease (NAFLD) in obese children.
Why this matters
- "[NAFLD] is the most common cause of chronic liver disease in obese children," say researchers. "Early diagnosis and treatment are essential for curing or slowing down the disease progression."
- Researchers studied obese pediatric patients both with and without NAFLD (n=108; age range, 6 years+2 months to 17 years+10 months; 50 boys).
- They assessed patient anthropometric measurements, NAFLD diagnosis, and metabolic syndrome (MS) components.
- Funding: Medical University of Silesia.
- NAFLD diagnosis rate was 45.4% (n=49) overall, with similar prevalence in boys (55.1%; n=27) and girls (44.9%; n=22; P=.089).
- MS was more likely in patients with NAFLD (40.82% vs 23.73%; P=.04).
- Researchers found that fasting insulin concentration with a cutoff point of 18.9 μIU/mL (area under the curve, 0.829) was the best independent predictor of NAFLD.
- The study was single-center with a small sample size.