- High cardiorespiratory fitness (CRF) level is linked to lower risk for lung cancer and colorectal cancer (CRC), and improved survival after diagnosis of either disease.
Why this matters
- Prior smaller studies lacked diversity with respect to sex and race.
- Henry Ford Exercise Testing (FIT) project involving 49,143 adults aged 40-70 (mean, 54.0) years who underwent exercise stress testing during 1991-2009 (46.1% female, 29.3% black, 0.7% Hispanic).
- CRF metabolic equivalents of task (METs) units categorized as
- Funding: Conquer Cancer Foundation.
- Average peak METs: 9.7 for men, 8.1 for women.
- 388 cases of lung cancer and 220 cases of CRC were diagnosed over a median 7.7-year follow-up.
- Highest vs lowest MET category was linked to:
- 77% decreased risk for lung cancer (HR, 0.23; 95% CI, 0.14-0.36).
- 61% decreased risk for CRC (HR, 0.39; 95% CI, 0.23-0.66).
- Risk for all-cause mortality in highest vs lowest MET category was:
- 44% lower after lung cancer diagnosis (HR, 0.56; 95% CI, 0.32-1.00).
- 89% lower after CRC diagnosis (HR, 0.11; 95% CI, 0.03-0.37).
- Increasing fitness inversely related to risks for lung cancer and CRC, subsequent mortality (all P<.01>
- Findings supported in sensitivity analysis addressing potential reverse causation.
- Single fitness assessment.
- Potential selection bias.